Thalidomide-PEG5-COOH

• CAT Number: I044488
• CAS Number: 2688100-28-7
• Molecular Formula: C24H30N2O11
• Molecular Weight: 522.50
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C24H30N2O11/c27-20-4-3-19(22(30)25-20)26-23(31)17-2-1-16(15-18(17)24(26)32)37-14-13-36-12-11-35-10-9-34-8-7-33-6-5-21(28)29/h1-2,15,19H,3-14H2,(H,28,29)(H,25,27,30)
• InChIKey: GORYVJWAUFWGOR-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCOCCOCCOCCOCCC(=O)O

Thalidomide-PEG5-COOH（Cat No.:I044488）is a hydrophilic, bifunctional linker used in the synthesis of PROTACs and other protein-targeting chimeras. It features a thalidomide moiety for cereblon E3 ligase recruitment, connected via a PEG5 (pentaethylene glycol) spacer to a terminal carboxylic acid group. The PEG5 chain enhances solubility, flexibility, and bioavailability while minimizing steric hindrance. The carboxylic acid allows efficient coupling with amine-bearing ligands or drug molecules. This extended, modular design supports precise spatial arrangement between protein-binding domains, aiding in the development of selective, potent degraders in chemical biology and therapeutic research.