Thalidomide-PEG4-COOH

• CAT Number: I044487
• CAS Number: 2828438-28-2
• Molecular Formula: C22H26N2O10
• Molecular Weight: 478.45
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]oxyethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C22H26N2O10/c25-18-4-3-17(20(28)23-18)24-21(29)15-2-1-14(13-16(15)22(24)30)34-12-11-33-10-9-32-8-7-31-6-5-19(26)27/h1-2,13,17H,3-12H2,(H,26,27)(H,23,25,28)
• InChIKey: JZAFPDYXTYKEQB-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCOCCOCCOCCC(=O)O

Thalidomide-PEG4-COOH（Cat No.:I044487）is a specialized bifunctional linker designed for use in PROTACs and other targeted therapeutic applications. It features a thalidomide moiety that recruits cereblon, a key E3 ubiquitin ligase, and a PEG4 (tetraethylene glycol) spacer that improves aqueous solubility, molecular flexibility, and reduces steric hindrance. The terminal carboxylic acid group enables straightforward conjugation to amine-containing ligands or drug warheads. This extended PEG linker allows for optimized spatial orientation between functional domains, enhancing the efficacy and selectivity of protein degradation strategies in chemical biology and modern drug design.