Thalidomide-PEG3-COOH

• CAT Number: I044486
• CAS Number: 2682112-08-7
• Molecular Formula: C20H22N2O9
• Molecular Weight: 434.40
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]oxyethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C20H22N2O9/c23-16-4-3-15(18(26)21-16)22-19(27)13-2-1-12(11-14(13)20(22)28)31-10-9-30-8-7-29-6-5-17(24)25/h1-2,11,15H,3-10H2,(H,24,25)(H,21,23,26)
• InChIKey: PZDWKEFNXUZNPV-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCOCCOCCC(=O)O

Thalidomide-PEG3-COOH（Cat No.:I044486）is a functionalized linker molecule widely used in the design of PROTACs and other bifunctional chemical probes. It consists of a thalidomide moiety for targeting the cereblon E3 ubiquitin ligase, connected via a PEG3 (triethylene glycol) spacer to a terminal carboxylic acid group. The PEG3 unit enhances water solubility, reduces steric clashes, and provides flexibility for optimal spatial arrangement. The carboxylic acid allows efficient coupling to amine-containing molecules. This linker facilitates the development of targeted protein degradation tools in chemical biology, drug discovery, and therapeutic innovation.