Thalidomide-PEG2-NH2 hydrochloride

• CAT Number: I042392
• CAS Number: 2891597-17-2
• Molecular Formula: C17H20ClN3O6
• Molecular Weight: 397.81
• Purity: ≥95%
• Synonyms: 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C17H19N3O6.ClH/c18-6-7-25-8-9-26-12-3-1-2-10-14(12)17(24)20(16(10)23)11-4-5-13(21)19-15(11)22;/h1-3,11H,4-9,18H2,(H,19,21,22);1H
• InChIKey: FTMOOQLGFVAFIK-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCCOCCN.Cl

Thalidomide-PEG2-NH2 hydrochloride (Cat No.: I042392) is a functionalized derivative of thalidomide featuring a short polyethylene glycol (PEG2) linker terminated with an amine group. This molecule is commonly used in the development of PROTACs (proteolysis-targeting chimeras) and other drug conjugates, enabling selective recruitment of E3 ubiquitin ligases such as cereblon for targeted protein degradation. The PEG2 spacer enhances solubility and flexibility, facilitating linker attachment to ligands or payloads. Its hydrochloride form ensures stability and ease of handling in medicinal chemistry and drug discovery applications.

Reference

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
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[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-996.
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