Thalidomide-PEG2-C2-NH2 hydrochloride

• CAT Number: I016390
• CAS Number: 2245697-87-2
• Molecular Formula: C19H25ClN4O6
• Molecular Weight: 440.88
• Purity: ≥95%
• Synonyms: 4-[2-[2-(2-aminoethoxy)ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C19H24N4O6.ClH/c20-6-8-28-10-11-29-9-7-21-13-3-1-2-12-16(13)19(27)23(18(12)26)14-4-5-15(24)22-17(14)25;/h1-3,14,21H,4-11,20H2,(H,22,24,25);1H
• InChIKey: BIBZEYIXXZHGNZ-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCN.Cl

Thalidomide-PEG2-C2-NH2 hydrochloride(CAT: I016390) is a functionalized thalidomide derivative designed as a building block for targeted protein degradation and related chemical biology applications. It consists of a thalidomide moiety linked via a short PEG2-C2 spacer to a terminal primary amine, provided as the stable hydrochloride salt. The thalidomide group serves as a cereblon (CRBN) ligand, commonly used in the design of PROTACs (proteolysis-targeting chimeras) and molecular glues. The PEG2-C2 spacer enhances solubility and provides conformational flexibility, while the terminal amine offers a reactive site for coupling to carboxyl or activated ester groups. This reagent is widely employed in drug discovery, chemical probe development, and targeted protein degradation research.