Thalidomide-O-PEG4-Boc

• CAT Number: I015696
• CAS Number: 2411681-87-1
• Molecular Formula: C28H38N2O11
• Molecular Weight: 578.61
• Purity: ≥95%
• Synonyms: tert-butyl 3-[2-[2-[2-[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C28H38N2O11/c1-28(2,3)41-23(32)9-10-36-11-12-37-13-14-38-15-16-39-17-18-40-21-6-4-5-19-24(21)27(35)30(26(19)34)20-7-8-22(31)29-25(20)33/h4-6,20H,7-18H2,1-3H3,(H,29,31,33)
• InChIKey: FBMJFOLUGBQIKU-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCCOCCOCCOC1=CC=CC2=C1C(=O)N(C2=O)C3CCC(=O)NC3=O

Thalidomide-O-PEG4-Boc（Cat No.:I015696）is a functionalized thalidomide derivative designed as a building block for PROTAC (proteolysis-targeting chimera) synthesis and related chemical biology applications. The thalidomide moiety recruits cereblon (CRBN), an E3 ubiquitin ligase component, enabling targeted protein degradation. The PEG4 spacer enhances solubility, flexibility, and reduces steric hindrance, while the Boc-protected amine serves as a handle for further synthetic modification. This reagent is widely used in medicinal chemistry and drug discovery to create bifunctional molecules that link CRBN binding with ligands for specific proteins, supporting therapeutic degrader development.