Thalidomide-O-C8-COOH

• CAT Number: I014976
• CAS Number: 2225148-51-4
• Molecular Formula: C22H26N2O7
• Molecular Weight: 430.45
• Purity: ≥95%
• Synonyms: 9-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxynonanoic acid
• InChI: InChI=1S/C22H26N2O7/c25-17-12-11-15(20(28)23-17)24-21(29)14-8-7-9-16(19(14)22(24)30)31-13-6-4-2-1-3-5-10-18(26)27/h7-9,15H,1-6,10-13H2,(H,26,27)(H,23,25,28)
• InChIKey: JDVPWEYIVOQCDX-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCCCCCCCCC(=O)O

Thalidomide-O-C8-COOH（Cat No.:I014976）is a functionalized thalidomide derivative modified with an eight-carbon carboxylic acid linker at the oxygen position. This structural extension allows conjugation to other molecules, making it valuable in chemical biology and drug design. As thalidomide is known for its immunomodulatory and anti-angiogenic properties, the C8-COOH variant is often used as a building block in PROTAC (proteolysis-targeting chimera) research, where it serves as the E3 ligase-binding ligand. Its design supports the creation of bifunctional molecules for targeted protein degradation and therapeutic exploration.