Thalidomide-O-C6-NHBoc

• CAT Number: I045224
• CAS Number: 2509093-23-4
• Molecular Formula: C24H31N3O7
• Molecular Weight: 473.52
• Purity: ≥95%
• Synonyms: tert-butyl N-[6-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyhexyl]carbamate
• InChI: InChI=1S/C24H31N3O7/c1-24(2,3)34-23(32)25-13-6-4-5-7-14-33-17-10-8-9-15-19(17)22(31)27(21(15)30)16-11-12-18(28)26-20(16)29/h8-10,16H,4-7,11-14H2,1-3H3,(H,25,32)(H,26,28,29)
• InChIKey: SWSPUYLZEIPCHI-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCCCCCOC1=CC=CC2=C1C(=O)N(C2=O)C3CCC(=O)NC3=O

Thalidomide-O-C6-NHBoc（Cat No.:I045224）is a bifunctional chemical intermediate featuring a thalidomide moiety linked via an alkyl (C6) spacer to a Boc-protected amine. The thalidomide unit serves as a cereblon (CRBN) ligand, enabling recruitment of the CRBN E3 ubiquitin ligase in proteolysis-targeting chimera (PROTAC) design. The C6 linker provides optimal flexibility and spatial orientation for conjugation to target-binding ligands, while the Boc group protects the amine during synthetic steps. This compound is widely used in medicinal chemistry for developing CRBN-based targeted protein degraders in chemical biology, oncology research, and therapeutic discovery.