Thalidomide-O-amido-PEG4-azide

• CAT Number: I015698
• CAS Number: 2411681-89-3
• Molecular Formula: C25H32N6O10
• Molecular Weight: 576.56
• Purity: ≥95%
• Synonyms: N-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethyl]-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide
• InChI: InChI=1S/C25H32N6O10/c26-30-28-7-9-38-11-13-40-15-14-39-12-10-37-8-6-27-21(33)16-41-19-3-1-2-17-22(19)25(36)31(24(17)35)18-4-5-20(32)29-23(18)34/h1-3,18H,4-16H2,(H,27,33)(H,29,32,34)
• InChIKey: XECAZVOTJVYNEM-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCOCCOCCOCCOCCN=[N+]=[N-]

Thalidomide-O-amido-PEG4-azide（Cat No.:I015698）is a functionalized thalidomide derivative designed as a versatile intermediate for PROTAC (proteolysis-targeting chimera) synthesis. The thalidomide moiety recruits cereblon (CRBN), an E3 ubiquitin ligase, to mediate targeted protein degradation. Its PEG4 linker improves solubility, flexibility, and reduces steric hindrance, enhancing conjugation efficiency. The terminal azide group enables copper-catalyzed or strain-promoted click chemistry, allowing efficient attachment to alkyne-bearing ligands or probes. This compound is widely used in chemical biology and medicinal chemistry to develop bifunctional degraders and investigate CRBN-based therapeutic protein knockdown strategies.