Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc

• CAT Number: I045166
• CAS Number: 1799711-31-1
• Molecular Formula: C30H42N4O11
• Molecular Weight: 634.67
• Purity: ≥95%
• Synonyms: tert-butyl N-[3-[2-[2-[3-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]propoxy]ethoxy]ethoxy]propyl]carbamate
• InChI: InChI=1S/C30H42N4O11/c1-30(2,3)45-29(40)32-12-6-14-42-16-18-43-17-15-41-13-5-11-31-24(36)19-44-22-8-4-7-20-25(22)28(39)34(27(20)38)21-9-10-23(35)33-26(21)37/h4,7-8,21H,5-6,9-19H2,1-3H3,(H,31,36)(H,32,40)(H,33,35,37)
• InChIKey: GUERDSNOMPTZOW-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCCOCCOCCOCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C2=O)C3CCC(=O)NC3=O

Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc（Cat No.:I045166）is a bifunctional chemical intermediate incorporating a thalidomide moiety linked via an amide bond to a PEG3 spacer, terminating with a Boc-protected amine. The thalidomide unit acts as a cereblon (CRBN) ligand, enabling targeted protein degradation in PROTAC design. The PEG3 linker imparts flexibility, solubility, and optimal spatial orientation for conjugation, while the Boc group protects the terminal amine during synthetic steps. This compound is widely used in medicinal chemistry for developing CRBN-based degraders in chemical biology, oncology research, and targeted therapeutic discovery.