Thalidomide-NH-PEG4-COOH

• CAT Number: I044564
• CAS Number: 2412056-48-3
• Molecular Formula: C24H31N3O10
• Molecular Weight: 521.52
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C24H31N3O10/c28-20-4-3-19(22(31)26-20)27-23(32)17-2-1-16(15-18(17)24(27)33)25-6-8-35-10-12-37-14-13-36-11-9-34-7-5-21(29)30/h1-2,15,19,25H,3-14H2,(H,29,30)(H,26,28,31)
• InChIKey: LKZFZWXIYMGKMH-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)NCCOCCOCCOCCOCCC(=O)O

Thalidomide-NH-PEG4-COOH（Cat No.:I044564）is a bifunctional linker molecule combining thalidomide, a ligand for the E3 ubiquitin ligase cereblon (CRBN), with a PEG4 spacer and a terminal carboxylic acid group. The PEG4 chain enhances solubility and provides structural flexibility, minimizing steric hindrance in conjugation reactions. The carboxylic acid group enables covalent attachment to amine-containing molecules via amide bond formation. Thalidomide-NH-PEG4-COOH is widely used in the design of PROTACs (proteolysis-targeting chimeras), facilitating targeted protein degradation by recruiting CRBN to specific proteins of interest for ubiquitination and subsequent proteasomal degradation.