Thalidomide-NH-PEG3-COOH

• CAT Number: I044490
• CAS Number: 2375283-62-6
• Molecular Formula: C22H27N3O9
• Molecular Weight: 477.46
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C22H27N3O9/c26-18-4-3-17(20(29)24-18)25-21(30)15-2-1-14(13-16(15)22(25)31)23-6-8-33-10-12-34-11-9-32-7-5-19(27)28/h1-2,13,17,23H,3-12H2,(H,27,28)(H,24,26,29)
• InChIKey: SYFPHSMLSPHFLO-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)NCCOCCOCCOCCC(=O)O

Thalidomide-NH-PEG3-COOH（Cat N0.:I044490）is a multifunctional linker designed for constructing PROTACs and related targeted therapeutics. It incorporates a thalidomide moiety that binds to cereblon E3 ligase, an amide (NH) linkage ensuring stable attachment, and a PEG3 (triethylene glycol) spacer that enhances water solubility, reduces steric hindrance, and improves molecular flexibility. The terminal carboxylic acid group allows for efficient conjugation with amine-containing ligands or drug molecules. This extended, hydrophilic linker design enables optimal spatial orientation between ligase and target-binding domains, supporting the development of selective protein degraders in chemical biology and drug discovery applications.