For research use only. Not for therapeutic Use.
Thalidomide-NH-C9-NH₂ hydrochloride(CAT: I040572) is a thalidomide-derived cereblon (CRBN) ligand equipped with a nine-carbon alkyl linker terminating in a primary amine, provided as a hydrochloride salt for improved handling and solubility. Designed for use in PROTAC (proteolysis-targeting chimera) development, this compound facilitates the recruitment of the CRBN E3 ubiquitin ligase complex to targeted proteins. The terminal amine enables straightforward conjugation to ligands, linkers, or reporter groups, supporting modular assembly of bifunctional degraders. Retaining the binding specificity of thalidomide for CRBN, this molecule is a valuable intermediate for targeted protein degradation strategies in cancer, immunology, and neurodegenerative disease research.
| CAS Number | 2305936-77-8 |
| Synonyms | 4-(9-aminononylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride |
| Molecular Formula | C22H31ClN4O4 |
| Purity | ≥95% |
| IUPAC Name | 4-(9-aminononylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride |
| InChI | InChI=1S/C22H30N4O4.ClH/c23-13-6-4-2-1-3-5-7-14-24-16-10-8-9-15-19(16)22(30)26(21(15)29)17-11-12-18(27)25-20(17)28;/h8-10,17,24H,1-7,11-14,23H2,(H,25,27,28);1H |
| InChIKey | NCVSGGBARHERSU-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCCCCCCN.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
