Thalidomide-NH-C6-NH-Boc

• CAT Number: I015162
• CAS Number: 2093536-13-9
• Molecular Formula: C24H32N4O6
• Molecular Weight: 472.53
• Purity: ≥95%
• Synonyms: tert-butyl N-[6-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexyl]carbamate
• InChI: InChI=1S/C24H32N4O6/c1-24(2,3)34-23(33)26-14-7-5-4-6-13-25-16-10-8-9-15-19(16)22(32)28(21(15)31)17-11-12-18(29)27-20(17)30/h8-10,17,25H,4-7,11-14H2,1-3H3,(H,26,33)(H,27,29,30)
• InChIKey: MYIJXYLTQWCASN-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCCCCCNC1=CC=CC2=C1C(=O)N(C2=O)C3CCC(=O)NC3=O

Thalidomide-NH-C6-NH-Boc（Cat No.:I015162）is a thalidomide-based derivative featuring a hexyl (C6) diamine spacer capped with a tert-butyloxycarbonyl (Boc) protecting group. The thalidomide moiety serves as a cereblon-binding ligand, commonly used in proteolysis-targeting chimera (PROTAC) design. The C6 linker provides optimal spacing for conjugation to a protein-targeting warhead, while the Boc group protects the terminal amine, allowing selective synthetic modifications. This intermediate is widely utilized in medicinal chemistry and chemical biology to develop targeted protein degraders, enabling precise exploration of structure–activity relationships in drug discovery research.