Thalidomide-NH-C4-NH-Boc

• CAT Number: I016956
• CAS Number: 2093388-52-2
• Molecular Formula: C22H28N4O6
• Molecular Weight: 444.48
• Purity: ≥95%
• Synonyms: tert-butyl N-[4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butyl]carbamate
• InChI: InChI=1S/C22H28N4O6/c1-22(2,3)32-21(31)24-12-5-4-11-23-14-8-6-7-13-17(14)20(30)26(19(13)29)15-9-10-16(27)25-18(15)28/h6-8,15,23H,4-5,9-12H2,1-3H3,(H,24,31)(H,25,27,28)
• InChIKey: OYPNLZMEXLFKLB-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCCCNC1=CC=CC2=C1C(=O)N(C2=O)C3CCC(=O)NC3=O

Thalidomide-NH-C4-NH-Boc(CAT: I016956) is a thalidomide-based bifunctional building block designed for use in medicinal chemistry and PROTAC (proteolysis-targeting chimera) research. It contains a thalidomide moiety that engages cereblon (CRBN), a key E3 ubiquitin ligase component, linked through a butyl (C4) spacer to a protected amine (Boc group). The Boc-protected amine provides synthetic flexibility, allowing for selective deprotection and subsequent coupling to target ligands, linkers, or reporter groups. This reagent is particularly useful for generating CRBN-recruiting conjugates in targeted protein degradation studies and drug discovery, enabling precise design of bifunctional molecules with controllable linker lengths and functionalization sites.