For research use only. Not for therapeutic Use.
Thalidomide-NH-C10-NH₂ hydrochloride(CAT: I040571) is a thalidomide-based derivative featuring a decyl (C10) alkyl linker terminating in a primary amine, supplied as a hydrochloride salt for enhanced solubility and stability. This compound is widely used as an E3 ligase ligand in the design of PROTACs (proteolysis-targeting chimeras) for targeted protein degradation. The terminal amine allows for facile conjugation to various warheads or linker systems. Retaining the CRBN-binding pharmacophore of thalidomide, it enables efficient recruitment of cereblon in protein degradation pathways. Ideal for chemical biology and drug discovery applications, this intermediate supports advanced research in targeted cancer and neurodegenerative disease therapies.
| CAS Number | 2460022-53-9 |
| Synonyms | 4-(10-aminodecylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride |
| Molecular Formula | C23H33ClN4O4 |
| Purity | ≥95% |
| IUPAC Name | 4-(10-aminodecylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride |
| InChI | InChI=1S/C23H32N4O4.ClH/c24-14-7-5-3-1-2-4-6-8-15-25-17-11-9-10-16-20(17)23(31)27(22(16)30)18-12-13-19(28)26-21(18)29;/h9-11,18,25H,1-8,12-15,24H2,(H,26,28,29);1H |
| InChIKey | BBQUPKKQVQXRBQ-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCCCCCCCN.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
