Thalidomide-5-PEG6-NH2 hydrochloride

• CAT Number: I040296
• Molecular Formula: C25H36ClN3O10
• Molecular Weight: 574.02
• Purity: ≥95%
• Synonyms: 5-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C25H35N3O10.ClH/c26-5-6-33-7-8-34-9-10-35-11-12-36-13-14-37-15-16-38-18-1-2-19-20(17-18)25(32)28(24(19)31)21-3-4-22(29)27-23(21)30;/h1-2,17,21H,3-16,26H2,(H,27,29,30);1H
• InChIKey: FMOYKLLSJRTZNL-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCOCCOCCOCCOCCOCCN.Cl

Thalidomide-5-PEG6-NH₂ hydrochloride(CAT: I040296) is a cereblon (CRBN)-recruiting ligand derived from thalidomide (HY-10984), featuring a hexaethylene glycol (PEG6) linker with a terminal amine at the 5-position. This PEGylated design enhances aqueous solubility, molecular flexibility, and pharmacokinetic profiles, making it ideal for incorporation into PROTACs (proteolysis-targeting chimeras). The molecule facilitates the recruitment of CRBN E3 ubiquitin ligase to a target protein ligand, promoting selective ubiquitination and proteasomal degradation. Supplied as a hydrochloride salt for improved stability and synthetic accessibility, Thalidomide-5-PEG6-NH₂ HCl is a valuable building block in the development of next-generation targeted protein degradation tools.