For research use only. Not for therapeutic Use.
Thalidomide-5-O-C7-NH₂ hydrochloride(CAT: I040320) is a thalidomide (HY-10984)-derived cereblon (CRBN) ligand functionalized with a 7-carbon alkylamino linker at the 5-position. It is engineered for use in PROTAC (proteolysis-targeting chimera) technology, where it facilitates CRBN recruitment to promote targeted protein ubiquitination and degradation via the ubiquitin-proteasome system. The C7 linker offers optimal proximity and flexibility for conjugation to a wide range of target-binding ligands. Provided as a hydrochloride salt to enhance solubility and stability, Thalidomide-5-O-C7-NH₂ HCl serves as a valuable intermediate in the development of custom degraders for cancer, immunology, and neurodegenerative disease research.
| Synonyms | 5-(7-aminoheptoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride |
| Molecular Formula | C20H26ClN3O5 |
| Purity | ≥95% |
| IUPAC Name | 5-(7-aminoheptoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride |
| InChI | InChI=1S/C20H25N3O5.ClH/c21-10-4-2-1-3-5-11-28-13-6-7-14-15(12-13)20(27)23(19(14)26)16-8-9-17(24)22-18(16)25;/h6-7,12,16H,1-5,8-11,21H2,(H,22,24,25);1H |
| InChIKey | SDZGHACKNWAAQJ-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCCCCCCN.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
