Thalidomide-5-O-C6-NH2 hydrochloride

• CAT Number: I040613
• CAS Number: 2761398-05-2
• Molecular Formula: C19H24ClN3O5
• Molecular Weight: 409.86
• Purity: ≥95%
• Synonyms: 5-(6-aminohexoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C19H23N3O5.ClH/c20-9-3-1-2-4-10-27-12-5-6-13-14(11-12)19(26)22(18(13)25)15-7-8-16(23)21-17(15)24;/h5-6,11,15H,1-4,7-10,20H2,(H,21,23,24);1H
• InChIKey: KNTMURBBEAVSHG-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCCCCCN.Cl

Thalidomide-5-O-C6-NH2 hydrochloride(CAT: I040613) is a functionalized derivative of thalidomide featuring an aminohexyl linker at the 5-O position, enabling facile conjugation for targeted drug delivery or PROTAC (proteolysis-targeting chimera) design. Retaining the cereblon-binding pharmacophore, it supports targeted protein degradation studies while offering enhanced synthetic versatility. This compound is especially useful in the development of bifunctional degraders, molecular probes, and delivery systems that exploit E3 ligase recruitment. Its modified structure allows for selective and stable linker attachment without compromising biological activity. Thalidomide-5-O-C6-NH2 hydrochloride is ideal for applications in chemical biology, medicinal chemistry, and targeted therapeutics research.