Thalidomide-5-O-C5-NH2 hydrochloride

• CAT Number: I040614
• CAS Number: 2761385-94-6
• Molecular Formula: C18H22ClN3O5
• Molecular Weight: 395.84
• Purity: ≥95%
• Synonyms: 5-(5-aminopentoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C18H21N3O5.ClH/c19-8-2-1-3-9-26-11-4-5-12-13(10-11)18(25)21(17(12)24)14-6-7-15(22)20-16(14)23;/h4-5,10,14H,1-3,6-9,19H2,(H,20,22,23);1H
• InChIKey: SOARARVJMPMSOU-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCCCCN.Cl

Thalidomide-5-O-C5-NH2 hydrochloride(CAT: I040614) is a thalidomide-based derivative modified with a pentylamine linker at the 5-O position, optimized for use in targeted protein degradation and drug conjugation strategies. The C5 alkyl chain offers a balance of flexibility and stability, enabling effective conjugation to ligands or payloads while preserving cereblon-binding functionality. This compound is frequently used in the design of PROTACs and other heterobifunctional molecules that leverage E3 ligase recruitment. Its structure supports efficient synthetic incorporation into complex therapeutic architectures, making it valuable for research in chemical biology, drug discovery, and next-generation therapeutic development platforms.