Thalidomide-5-O-C4-NH2 hydrochloride

• CAT Number: I040615
• CAS Number: 2694727-93-8
• Molecular Formula: C17H20ClN3O5
• Molecular Weight: 381.81
• Purity: ≥95%
• Synonyms: 5-(4-aminobutoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C17H19N3O5.ClH/c18-7-1-2-8-25-10-3-4-11-12(9-10)17(24)20(16(11)23)13-5-6-14(21)19-15(13)22;/h3-4,9,13H,1-2,5-8,18H2,(H,19,21,22);1H
• InChIKey: UXTCSUBMRQWFPY-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCCCN.Cl

Thalidomide-5-O-C4-NH2 hydrochloride(CAT: I040615) is a cereblon-binding thalidomide analog featuring a butylamine (C4) linker at the 5-hydroxy position, engineered for use in targeted protein degradation research. The four-carbon spacer offers compact linker geometry suitable for constructing PROTACs and molecular conjugates where steric control is critical. This compound enables precise attachment to warheads or other targeting moieties while retaining E3 ligase recruitment capability. Its streamlined structure supports applications in medicinal chemistry, chemical biology, and ligand-directed degradation strategies. Thalidomide-5-O-C4-NH2 hydrochloride is a versatile intermediate for generating cereblon-recruiting conjugates in the development of next-generation therapeutic modalities.