Thalidomide-5-O-C3-NH2 hydrochloride

• CAT Number: I040616
• CAS Number: 2694727-94-9
• Molecular Formula: C16H18ClN3O5
• Molecular Weight: 367.78
• Purity: ≥95%
• Synonyms: 5-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C16H17N3O5.ClH/c17-6-1-7-24-9-2-3-10-11(8-9)16(23)19(15(10)22)12-4-5-13(20)18-14(12)21;/h2-3,8,12H,1,4-7,17H2,(H,18,20,21);1H
• InChIKey: DNABZKGLAFRGIL-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCCN.Cl

Thalidomide-5-O-C3-NH2 hydrochloride(CAT: I040616) is a compact thalidomide derivative functionalized with a propylamine (C3) linker at the 5-O position, tailored for applications in targeted protein degradation and molecular conjugation. Its short, three-carbon chain offers minimal spatial extension, making it ideal for PROTAC designs requiring tight spatial control or steric constraint around the cereblon-binding moiety. This molecule facilitates efficient attachment to ligands or reactive groups without compromising E3 ligase engagement. Widely used in chemical biology and drug design, Thalidomide-5-O-C3-NH2 hydrochloride is a valuable tool for building precise, modular therapeutics and studying cereblon-mediated ubiquitination pathways.