Thalidomide-5-O-C14-NH2 hydrochloride

• CAT Number: I040313
• Molecular Formula: C27H40ClN3O5
• Molecular Weight: 522.08
• Purity: ≥95%
• Synonyms: 5-(14-aminotetradecoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C27H39N3O5.ClH/c28-17-11-9-7-5-3-1-2-4-6-8-10-12-18-35-20-13-14-21-22(19-20)27(34)30(26(21)33)23-15-16-24(31)29-25(23)32;/h13-14,19,23H,1-12,15-18,28H2,(H,29,31,32);1H
• InChIKey: RIEYOYMQRJMSEQ-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCCCCCCCCCCCCCN.Cl

Thalidomide-5-O-C14-NH₂ hydrochloride(CAT: I040313) is a cereblon (CRBN)-binding ligand derived from thalidomide (HY-10984), functionalized with a 14-carbon alkylamino chain at the 5-position and provided as a hydrochloride salt for enhanced solubility and stability. This compound is specifically designed for use in PROTAC (proteolysis-targeting chimera) synthesis, where it enables the recruitment of the CRBN E3 ubiquitin ligase to a target protein. The extended C14 linker offers versatility for conjugation to diverse protein-targeting ligands, facilitating selective degradation of disease-relevant proteins. Thalidomide-5-O-C14-NH₂ HCl is ideal for targeted protein degradation research and rational PROTAC design.