Thalidomide-5-O-C13-NH2 hydrochloride

• CAT Number: I040314
• Molecular Formula: C26H38ClN3O5
• Molecular Weight: 508.05
• Purity: ≥95%
• Synonyms: 5-(13-aminotridecoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C26H37N3O5.ClH/c27-16-10-8-6-4-2-1-3-5-7-9-11-17-34-19-12-13-20-21(18-19)26(33)29(25(20)32)22-14-15-23(30)28-24(22)31;/h12-13,18,22H,1-11,14-17,27H2,(H,28,30,31);1H
• InChIKey: OKOWXHFKZIMFFM-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCCCCCCCCCCCCN.Cl

Thalidomide-5-O-C13-NH₂ hydrochloride(CAT: I040314) is a cereblon (CRBN)-recruiting ligand derived from thalidomide (HY-10984), functionalized with a 13-carbon alkylamino linker at the 5-position. This compound is specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras), enabling the recruitment of the CRBN E3 ubiquitin ligase to targeted proteins. The C13 linker offers optimal length and flexibility for conjugation to various ligands, facilitating efficient ternary complex formation and subsequent protein degradation. Supplied as a hydrochloride salt to enhance solubility and stability, Thalidomide-5-O-C13-NH₂ HCl is a valuable building block in targeted protein degradation and chemical biology research.