Thalidomide-5-O-C12-NH2 hydrochloride

• CAT Number: I040315
• Molecular Formula: C25H36ClN3O5
• Molecular Weight: 494.02
• Purity: ≥95%
• Synonyms: 5-(12-aminododecoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C25H35N3O5.ClH/c26-15-9-7-5-3-1-2-4-6-8-10-16-33-18-11-12-19-20(17-18)25(32)28(24(19)31)21-13-14-22(29)27-23(21)30;/h11-12,17,21H,1-10,13-16,26H2,(H,27,29,30);1H
• InChIKey: JYPKFYAFLVGEJI-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCCCCCCCCCCCN.Cl

Thalidomide-5-O-C12-NH₂ hydrochloride(CAT: I040315) is a thalidomide (HY-10984)-derived cereblon (CRBN) ligand functionalized with a 12-carbon alkylamino linker at the 5-position. Designed for use in PROTAC (proteolysis-targeting chimera) development, this compound facilitates the recruitment of the CRBN E3 ubiquitin ligase, enabling selective degradation of target proteins. The C12 linker offers optimal spatial flexibility for conjugation with diverse protein-targeting ligands. Supplied as a hydrochloride salt to enhance solubility and synthetic utility, Thalidomide-5-O-C12-NH₂ HCl is ideal for constructing bifunctional degraders in cancer research, immunology, and targeted protein degradation studies.