Thalidomide-5-O-C11-NH2 hydrochloride

• CAT Number: I040316
• Molecular Formula: C24H34ClN3O5
• Molecular Weight: 480.00
• Purity: ≥95%
• Synonyms: 5-(11-aminoundecoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C24H33N3O5.ClH/c25-14-8-6-4-2-1-3-5-7-9-15-32-17-10-11-18-19(16-17)24(31)27(23(18)30)20-12-13-21(28)26-22(20)29;/h10-11,16,20H,1-9,12-15,25H2,(H,26,28,29);1H
• InChIKey: XWQGSUYZVUVCPA-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCCCCCCCCCCN.Cl

Thalidomide-5-O-C11-NH₂ hydrochloride(CAT: I040316) is a thalidomide (HY-10984)-based cereblon (CRBN) ligand functionalized with an 11-carbon alkylamino linker at the 5-position. It is specifically designed for use in PROTAC (proteolysis-targeting chimera) technology, where it recruits the CRBN E3 ubiquitin ligase complex to enable targeted protein ubiquitination and degradation. The C11 linker provides suitable flexibility and spacing for conjugation with various protein-targeting ligands, facilitating efficient ternary complex formation. Supplied as a hydrochloride salt to improve solubility and chemical stability, Thalidomide-5-O-C11-NH₂ HCl is an essential intermediate for constructing custom degraders in cancer, immunology, and neurodegenerative disease research.