For research use only. Not for therapeutic Use.
Thalidomide-5-O-C10-NH₂ hydrochloride(CAT: I040317) is a thalidomide (HY-10984)-derived cereblon (CRBN) ligand engineered for targeted protein degradation via PROTAC (proteolysis-targeting chimera) technology. Featuring a 10-carbon alkylamino linker at the 5-position, this compound efficiently recruits CRBN, a substrate receptor of the E3 ubiquitin ligase complex. The terminal amine provides a reactive site for conjugation with target-binding ligands, enabling the formation of heterobifunctional molecules that direct specific proteins for ubiquitination and degradation. Offered as a hydrochloride salt for enhanced solubility and handling, Thalidomide-5-O-C10-NH₂ HCl is ideal for designing custom PROTACs in cancer, inflammation, and neurodegenerative disease research.
| Synonyms | 5-(10-aminodecoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride |
| Molecular Formula | C23H32ClN3O5 |
| Purity | ≥95% |
| IUPAC Name | 5-(10-aminodecoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride |
| InChI | InChI=1S/C23H31N3O5.ClH/c24-13-7-5-3-1-2-4-6-8-14-31-16-9-10-17-18(15-16)23(30)26(22(17)29)19-11-12-20(27)25-21(19)28;/h9-10,15,19H,1-8,11-14,24H2,(H,25,27,28);1H |
| InChIKey | CLCNTSDSFGDPEU-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCCCCCCCCCN.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
