Thalidomide-4-O-C7-NH2 hydrochloride

• CAT Number: I040335
• Molecular Formula: C20H26ClN3O5
• Molecular Weight: 423.89
• Purity: ≥95%
• Synonyms: 4-(7-aminoheptoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C20H25N3O5.ClH/c21-11-4-2-1-3-5-12-28-15-8-6-7-13-17(15)20(27)23(19(13)26)14-9-10-16(24)22-18(14)25;/h6-8,14H,1-5,9-12,21H2,(H,22,24,25);1H
• InChIKey: FCDCMELZMHFKJE-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCCCCCCCN.Cl

Thalidomide-4-O-C7-NH₂ hydrochloride(CAT: I040335) is a thalidomide (HY-10984)-based cereblon (CRBN) ligand functionalized with a 7-carbon alkylamino linker at the 4-position, designed for targeted protein degradation applications. This compound enables the recruitment of the CRBN E3 ubiquitin ligase complex in PROTAC (proteolysis-targeting chimera) constructs. The terminal amine facilitates conjugation to protein-targeting ligands, forming bifunctional molecules that induce ubiquitination and proteasomal degradation of disease-relevant proteins. Supplied as a hydrochloride salt to enhance solubility and chemical stability, Thalidomide-4-O-C7-NH₂ HCl is an essential intermediate in the rational design of degraders for oncology, immunology, and neurodegeneration research.