Thalidomide-4-O-C5-NH2 hydrochloride

• CAT Number: I044467
• CAS Number: 2419145-66-5
• Molecular Formula: C18H22ClN3O5
• Molecular Weight: 395.84
• Purity: ≥95%
• Synonyms: 4-(5-aminopentoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C18H21N3O5.ClH/c19-9-2-1-3-10-26-13-6-4-5-11-15(13)18(25)21(17(11)24)12-7-8-14(22)20-16(12)23;/h4-6,12H,1-3,7-10,19H2,(H,20,22,23);1H
• InChIKey: FKODABBSPDGXGQ-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCCCCCN.Cl

Thalidomide-4-O-C5-NH2 hydrochloride（Cat No.:I044467）is a functionalized derivative of thalidomide engineered for use in the development of PROTACs (proteolysis-targeting chimeras). It features a five-carbon linker with a terminal amine group at the 4-position of the thalidomide core, allowing for conjugation to ligands targeting proteins of interest. The molecule retains its ability to bind cereblon (CRBN), a substrate receptor of the CRL4 E3 ubiquitin ligase complex, facilitating targeted protein degradation. The hydrochloride salt improves solubility and handling. This compound is ideal for constructing CRBN-recruiting bifunctional degraders in chemical biology and drug discovery.