Thalidomide-4-O-C14-NH2 hydrochloride

• CAT Number: I040310
• Molecular Formula: C27H40ClN3O5
• Molecular Weight: 522.08
• Purity: ≥95%
• Synonyms: 4-(14-aminotetradecoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C27H39N3O5.ClH/c28-18-11-9-7-5-3-1-2-4-6-8-10-12-19-35-22-15-13-14-20-24(22)27(34)30(26(20)33)21-16-17-23(31)29-25(21)32;/h13-15,21H,1-12,16-19,28H2,(H,29,31,32);1H
• InChIKey: QAUYZMOOLBGWBF-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCCCCCCCCCCCCCCN.Cl

Thalidomide-4-O-C14-NH₂ hydrochloride(CAT: I040310) is a thalidomide (HY-10984)-derived cereblon (CRBN) ligand functionalized with a 14-carbon alkylamino linker at the 4-position. It is specifically engineered for use in PROTAC (proteolysis-targeting chimera) design, enabling the recruitment of the CRBN E3 ubiquitin ligase to mediate selective degradation of target proteins. The extended C14 linker provides ample flexibility and spatial reach for conjugation to diverse ligands, optimizing ternary complex formation and proteasomal degradation efficiency. Supplied as a hydrochloride salt to enhance solubility and stability, Thalidomide-4-O-C14-NH₂ HCl is ideal for chemical biology, targeted protein degradation, and drug discovery research.