Thalidomide-4-O-C12-NH2 hydrochloride

• CAT Number: I040311
• Molecular Formula: C25H36ClN3O5
• Molecular Weight: 494.02
• Purity: ≥95%
• Synonyms: 4-(12-aminododecoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C25H35N3O5.ClH/c26-16-9-7-5-3-1-2-4-6-8-10-17-33-20-13-11-12-18-22(20)25(32)28(24(18)31)19-14-15-21(29)27-23(19)30;/h11-13,19H,1-10,14-17,26H2,(H,27,29,30);1H
• InChIKey: ZNEQRIRWIFHMKT-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCCCCCCCCCCCCN.Cl

Thalidomide-4-O-C12-NH₂ hydrochloride(CAT: I040311) is a cereblon (CRBN)-recruiting ligand derived from thalidomide, functionalized with a 12-carbon alkylamino side chain at the 4-position. This compound is designed for use in PROTAC (proteolysis-targeting chimera) development, where it facilitates the recruitment of the CRBN E3 ubiquitin ligase to induce targeted protein degradation. The C12 linker provides optimal spacing for conjugation to various target ligands, supporting efficient ternary complex formation and selective ubiquitination. Supplied as a hydrochloride salt to enhance aqueous solubility and synthetic accessibility, Thalidomide-4-O-C12-NH₂ HCl is an essential building block in chemical biology and targeted protein degradation research.