Thalidomide-4-O-C11-NH2 hydrochloride

• CAT Number: I040312
• Molecular Formula: C24H34ClN3O5
• Molecular Weight: 480.00
• Purity: ≥95%
• Synonyms: 4-(11-aminoundecoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C24H33N3O5.ClH/c25-15-8-6-4-2-1-3-5-7-9-16-32-19-12-10-11-17-21(19)24(31)27(23(17)30)18-13-14-20(28)26-22(18)29;/h10-12,18H,1-9,13-16,25H2,(H,26,28,29);1H
• InChIKey: AMCVOZMMQNDGDF-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCCCCCCCCCCCN.Cl

Thalidomide-4-O-C11-NH₂ hydrochloride(CAT: I040312) is a thalidomide (HY-10984)-derived cereblon (CRBN) ligand functionalized with an 11-carbon alkylamino linker at the 4-position. This compound is engineered for use in PROTAC (proteolysis-targeting chimera) applications, where it enables recruitment of the CRBN E3 ubiquitin ligase complex to direct target proteins for ubiquitination and degradation. The C11 linker provides optimal flexibility and spacing for conjugation to various protein-targeting ligands. Supplied as a hydrochloride salt to enhance solubility and handling, Thalidomide-4-O-C11-NH₂ HCl is ideal for designing custom degraders in cancer biology, immunotherapy, and targeted protein degradation research.