Thalidomide-4-O-C10-NH2 hydrochloride

• CAT Number: I040334
• Molecular Formula: C23H32ClN3O5
• Molecular Weight: 465.97
• Purity: ≥95%
• Synonyms: 4-(10-aminodecoxy)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C23H31N3O5.ClH/c24-14-7-5-3-1-2-4-6-8-15-31-18-11-9-10-16-20(18)23(30)26(22(16)29)17-12-13-19(27)25-21(17)28;/h9-11,17H,1-8,12-15,24H2,(H,25,27,28);1H
• InChIKey: RRUNFXOOHPKFCR-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCCCCCCCCCCN.Cl

Thalidomide-4-O-C10-NH₂ hydrochloride(CAT: I040334) is a thalidomide-based derivative functionalized with a decyl (C10) aminoalkyl side chain via an ether linkage at the 4-position, and presented as a stable hydrochloride salt. This compound is engineered for use in targeted protein degradation studies, particularly as a cereblon (CRBN) E3 ligase-binding ligand in PROTAC (proteolysis-targeting chimera) development. The extended alkylamino linker provides flexibility for conjugation to various warheads, enabling degradation of disease-relevant proteins. Its structural design retains CRBN affinity while enhancing solubility and chemical versatility. Thalidomide-4-O-C10-NH₂ hydrochloride is ideal for chemical biology and drug discovery research.