For research use only. Not for therapeutic Use.
TH470 (Cat No.: I042608) is a potent and selective dual inhibitor of lactate dehydrogenase A (LDHA) and lactate dehydrogenase B (LDHB), key enzymes involved in glycolysis and cellular energy metabolism. By blocking LDH activity, TH470 disrupts the conversion of pyruvate to lactate, thereby reducing lactate production and impairing metabolic flexibility in cancer cells. This inhibition affects tumor growth, particularly under hypoxic conditions. TH470 is a valuable research tool for studying cancer metabolism and exploring therapeutic strategies that target metabolic vulnerabilities in tumors.
| CAS Number | 2834739-51-2 |
| Synonyms | N-[2-[benzyl-[4-(phenylsulfamoyl)benzoyl]amino]ethyl]-2-(2-methylpropanoylamino)-1,3-thiazole-5-carboxamide |
| Molecular Formula | C30H31N5O5S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C30H31N5O5S2/c1-21(2)27(36)33-30-32-19-26(41-30)28(37)31-17-18-35(20-22-9-5-3-6-10-22)29(38)23-13-15-25(16-14-23)42(39,40)34-24-11-7-4-8-12-24/h3-16,19,21,34H,17-18,20H2,1-2H3,(H,31,37)(H,32,33,36) |
| InChIKey | YVPYJSSYGACUSE-UHFFFAOYSA-N |
| SMILES | CC(C)C(=O)NC1=NC=C(S1)C(=O)NCCN(CC2=CC=CC=C2)C(=O)C3=CC=C(C=C3)S(=O)(=O)NC4=CC=CC=C4 |
| Reference | [1]. Hanke T, et al. Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. J Med Chem. 2022 Oct 13;65(19):13264-13287. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
