TH1338

• CAT Number: I037183
• CAS Number: 1258494-60-8
• Molecular Formula: C22H21N3O4
• Molecular Weight: 391.42
• Purity: ≥95%
• Synonyms: (19S)-21-amino-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• InChI: InChI=1S/C22H21N3O4/c1-3-11-12-7-5-6-8-15(12)24-18-13(11)9-25-19(18)17(23)16-14(20(25)26)10-29-21(27)22(16,28)4-2/h5-8,28H,3-4,9-10,23H2,1-2H3/t22-/m0/s1
• InChIKey: GDSWDKUWTYXXOX-QFIPXVFZSA-N
• SMILES: CCC1=C2CN3C(=C(C4=C(C3=O)COC(=O)C4(CC)O)N)C2=NC5=CC=CC=C51

TH1338 (Cat No.: I037183) is a small-molecule inhibitor that selectively targets ubiquitin-specific protease 7 (USP7), a deubiquitinating enzyme involved in protein stability, DNA repair, and epigenetic regulation. By blocking USP7 activity, TH1338 promotes degradation of oncogenic proteins and disrupts pathways that support tumor cell survival. It has been studied in preclinical models as a potential anticancer agent, particularly in malignancies where USP7 is overactive. TH1338 serves as a valuable chemical probe for investigating ubiquitin signaling and developing targeted anticancer therapies.

Reference

[1]. Jian-Xin Duan, et al. 14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment. J Med Chem. 2011 Mar 24;54(6):1715-23.
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[2]. Xia Cheng, et al. Preparation, Characterization, and In Vivo Study of 7-Ethyl-14-Aminocamptothecin-Loaded Poly(Ethylene Glycol)2000 -Poly(Lactic Acid)2000 Polymeric Micelles Against H460 Human Nonsmall Cell Lung Carcinoma. J Pharm Sci. 2015 Nov;104(11):3934-3942.
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