For research use only. Not for therapeutic Use.
TH-Z93 (Cat No.: I042613) is a potent and selective covalent inhibitor targeting the KRAS G12D mutant, a driver mutation frequently found in pancreatic, colorectal, and lung cancers. By irreversibly binding to the mutant KRAS G12D protein, TH-Z93 blocks its ability to activate downstream signaling pathways such as MAPK and PI3K-AKT, thereby inhibiting tumor cell proliferation and survival. Its high specificity minimizes off-target effects, making it a valuable tool for studying KRAS-driven oncogenesis and advancing targeted cancer therapy strategies in preclinical research models.
CAS Number | 2260887-09-8 |
Synonyms | [[(4-hexoxypyridin-2-yl)amino]-phosphonomethyl]phosphonic acid |
Molecular Formula | C12H22N2O7P2 |
Purity | ≥95% |
InChI | InChI=1S/C12H22N2O7P2/c1-2-3-4-5-8-21-10-6-7-13-11(9-10)14-12(22(15,16)17)23(18,19)20/h6-7,9,12H,2-5,8H2,1H3,(H,13,14)(H2,15,16,17)(H2,18,19,20) |
InChIKey | NXVHNJBPVOSZAP-UHFFFAOYSA-N |
SMILES | CCCCCCOC1=CC(=NC=C1)NC(P(=O)(O)O)P(=O)(O)O |
Reference | [1]. Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21. |
Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |