TH-Z93

• CAT Number: I042613
• CAS Number: 2260887-09-8
• Molecular Formula: C12H22N2O7P2
• Molecular Weight: 368.26
• Purity: ≥95%
• Synonyms: [[(4-hexoxypyridin-2-yl)amino]-phosphonomethyl]phosphonic acid
• InChI: InChI=1S/C12H22N2O7P2/c1-2-3-4-5-8-21-10-6-7-13-11(9-10)14-12(22(15,16)17)23(18,19)20/h6-7,9,12H,2-5,8H2,1H3,(H,13,14)(H2,15,16,17)(H2,18,19,20)
• InChIKey: NXVHNJBPVOSZAP-UHFFFAOYSA-N
• SMILES: CCCCCCOC1=CC(=NC=C1)NC(P(=O)(O)O)P(=O)(O)O

TH-Z93 (Cat No.: I042613) is a potent and selective covalent inhibitor targeting the KRAS G12D mutant, a driver mutation frequently found in pancreatic, colorectal, and lung cancers. By irreversibly binding to the mutant KRAS G12D protein, TH-Z93 blocks its ability to activate downstream signaling pathways such as MAPK and PI3K-AKT, thereby inhibiting tumor cell proliferation and survival. Its high specificity minimizes off-target effects, making it a valuable tool for studying KRAS-driven oncogenesis and advancing targeted cancer therapy strategies in preclinical research models.

Reference

[1]. Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21.
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