TH-257

For research use only. Not for therapeutic Use.

  • CAT Number: I017876
  • CAS Number: 2244678-29-1
  • Molecular Formula: C24H26N2O3S
  • Molecular Weight: 422.54
  • Purity: ≥95%
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TH-257(Cat No.:I017876)is a potent and selective inhibitor of LIM kinase 1/2 (LIMK1/2), enzymes that regulate actin cytoskeleton dynamics by phosphorylating cofilin. By blocking LIMK activity, TH-257 prevents cofilin inactivation, leading to actin filament depolymerization and cytoskeletal remodeling. This compound is a valuable research tool for studying cell motility, invasion, and neuronal plasticity. TH-257 has applications in cancer, neuroscience, and fibrosis research, where actin dynamics play critical roles. Its strong potency and cellular activity make it useful for probing LIMK-dependent signaling and therapeutic potential.


CAS Number 2244678-29-1
Synonyms

N-benzyl-N-butyl-4-(phenylsulfamoyl)benzamide

Molecular Formula C24H26N2O3S
Purity ≥95%
IUPAC Name N-benzyl-N-butyl-4-(phenylsulfamoyl)benzamide
InChI InChI=1S/C24H26N2O3S/c1-2-3-18-26(19-20-10-6-4-7-11-20)24(27)21-14-16-23(17-15-21)30(28,29)25-22-12-8-5-9-13-22/h4-17,25H,2-3,18-19H2,1H3
InChIKey VNCIWNGCMAKKEO-UHFFFAOYSA-N
SMILES CCCCN(CC1=CC=CC=C1)C(=O)C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=C3
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