TGN-020 sodium

• CAT Number: I042519
• CAS Number: 1313731-99-5
• Molecular Formula: C8H5N4NaOS
• Molecular Weight: 228.21
• Purity: ≥95%
• Synonyms: sodium;pyridine-3-carbonyl(1,3,4-thiadiazol-2-yl)azanide
• InChI: InChI=1S/C8H6N4OS.Na/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8;/h1-5H,(H,11,12,13);/q;+1/p-1
• InChIKey: YVHWOCDMDRVSHB-UHFFFAOYSA-M
• SMILES: C1=CC(=CN=C1)C(=O)[N-]C2=NN=CS2.[Na+]

TGN-020 sodium (Cat No.: I042519) is a selective inhibitor of aquaporin-4 (AQP4), a water channel protein predominantly expressed in the central nervous system, especially in astrocytes. By blocking AQP4, TGN-020 reduces water permeability across cell membranes, making it a valuable tool for studying brain edema, neuroinflammation, and disorders such as neuromyelitis optica. It has shown therapeutic potential in conditions involving disrupted water homeostasis. TGN-020 sodium is widely used in preclinical research to explore AQP4’s role in brain physiology and neurological disease mechanisms.

Reference

[1]. Vincent J Huber, et al. Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg Med Chem. 2009 Jan 1;17(1):411-7.
[Content Brief]

[2]. Shou Oosuka, et al. Effects of an Aquaporin 4 Inhibitor, TGN-020, on Murine Diabetic Retina. Int J Mol Sci. 2020 Mar 27;21(7):2324.
[Content Brief]

[3]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
[Content Brief]

[4]. Jian Li, et al. TGN-020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats. Life Sci. 2019 Apr 1;222:148-157.
[Content Brief]