For research use only. Not for therapeutic Use.
TFMU-ADPr diammonium(CAT: I040325) is a fluorogenic ADP-ribosylated substrate analog incorporating a 2′,4′,5′-trifluoromethylumbelliferone (TFMU) fluorophore. Designed for biochemical assays, it serves as a sensitive probe to monitor ADP-ribosylation and its reversal by hydrolases such as macrodomains, ARH (ADP-ribosylhydrolase) family members, and other enzymes involved in ADP-ribose metabolism. Upon enzymatic cleavage, TFMU is released, emitting a fluorescent signal ideal for high-throughput screening and kinetic studies. Supplied as a diammonium salt for improved solubility and assay compatibility, TFMU-ADPr is an essential research tool for studying ADP-ribosylation pathways in cancer, inflammation, and antiviral responses.
| Synonyms | [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4-dihydroxy-5-[2-oxo-4-(trifluoromethyl)chromen-7-yl]oxyoxolan-2-yl]methyl hydrogen phosphate;azane |
| Molecular Formula | C25H32F3N7O16P2 |
| Purity | ≥95% |
| IUPAC Name | [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4-dihydroxy-5-[2-oxo-4-(trifluoromethyl)chromen-7-yl]oxyoxolan-2-yl]methyl hydrogen phosphate;azane |
| InChI | InChI=1S/C25H26F3N5O16P2.2H3N/c26-25(27,28)11-4-15(34)46-12-3-9(1-2-10(11)12)45-24-20(38)18(36)14(48-24)6-44-51(41,42)49-50(39,40)43-5-13-17(35)19(37)23(47-13)33-8-32-16-21(29)30-7-31-22(16)33;;/h1-4,7-8,13-14,17-20,23-24,35-38H,5-6H2,(H,39,40)(H,41,42)(H2,29,30,31);2*1H3/t13-,14-,17-,18-,19-,20-,23-,24+;;/m1../s1 |
| InChIKey | GEZILDRURLNQDR-HXERXLDDSA-N |
| SMILES | C1=CC2=C(C=C1OC3C(C(C(O3)COP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)O)O)O)O)OC(=O)C=C2C(F)(F)F.N.N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
