For research use only. Not for therapeutic Use.
TFB-TBOA (Cat No.:I010577) is a high-affinity, non-transportable inhibitor of excitatory amino acid transporters (EAATs), particularly EAAT1, EAAT2, and EAAT3. By blocking glutamate reuptake, TFB-TBOA increases extracellular glutamate concentrations, making it a powerful tool for studying glutamatergic neurotransmission, excitotoxicity, and synaptic plasticity. It is widely used in neuroscience research to model conditions like stroke, epilepsy, and neurodegenerative diseases where dysregulated glutamate signaling plays a key role. TFB-TBOA’s potent and selective inhibition makes it valuable for probing the physiological and pathological roles of EAATs in the central nervous system.
| CAS Number | 480439-73-4 |
| Synonyms | (2S,3S)-2-amino-3-[[3-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methoxy]butanedioic acid |
| Molecular Formula | C19H17F3N2O6 |
| Purity | ≥95% |
| IUPAC Name | (2S,3S)-2-amino-3-[[3-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methoxy]butanedioic acid |
| InChI | InChI=1S/C19H17F3N2O6/c20-19(21,22)12-6-4-11(5-7-12)16(25)24-13-3-1-2-10(8-13)9-30-15(18(28)29)14(23)17(26)27/h1-8,14-15H,9,23H2,(H,24,25)(H,26,27)(H,28,29)/t14-,15-/m0/s1 |
| InChIKey | LPWONNPEPDHEAI-GJZGRUSLSA-N |
| SMILES | C1=CC(=CC(=C1)NC(=O)C2=CC=C(C=C2)C(F)(F)F)CO[C@@H]([C@@H](C(=O)O)N)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
