For research use only. Not for therapeutic Use.
Tetrazine-Ph-acid(CAT: I016411) is a reactive tetrazine derivative featuring a phenyl linker and a terminal carboxylic acid group, designed for use in bioorthogonal chemistry and advanced conjugation strategies. The tetrazine moiety undergoes rapid and selective inverse electron-demand Diels–Alder (IEDDA) cycloaddition with strained alkenes or alkynes (such as trans-cyclooctenes), enabling efficient bioconjugation under mild conditions. The phenyl spacer provides rigidity, while the terminal acid allows further functionalization or coupling to biomolecules. Tetrazine-Ph-acid is widely applied in chemical biology, imaging, drug delivery, and material science, supporting precise labeling and click chemistry approaches in both in vitro and in vivo systems.
| CAS Number | 1380500-92-4 |
| Synonyms | 2-[4-(1,2,4,5-tetrazin-3-yl)phenyl]acetic acid |
| Molecular Formula | C10H8N4O2 |
| Purity | ≥95% |
| IUPAC Name | 2-[4-(1,2,4,5-tetrazin-3-yl)phenyl]acetic acid |
| InChI | InChI=1S/C10H8N4O2/c15-9(16)5-7-1-3-8(4-2-7)10-13-11-6-12-14-10/h1-4,6H,5H2,(H,15,16) |
| InChIKey | SLJKKTFIAUAYGR-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1CC(=O)O)C2=NN=CN=N2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
