For research use only. Not for therapeutic Use.
Tetrazine-PEG4-amine hydrochloride（Cat No.:I045861）is a heterobifunctional linker widely used in bioorthogonal chemistry, particularly in inverse electron-demand Diels–Alder (IEDDA) reactions. The tetrazine moiety reacts rapidly and selectively with strained alkenes or alkynes, enabling efficient bioconjugation under physiological conditions. The PEG4 spacer enhances solubility and reduces steric hindrance, while the terminal amine provides a versatile handle for coupling to biomolecules, peptides, or surfaces. Supplied as a stable hydrochloride salt, this reagent is ideal for constructing antibody–drug conjugates, imaging probes, and other targeted therapeutic systems in chemical biology and biomedical research.
| CAS Number | 2752945-36-9 |
| Synonyms | 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methyl]propanamide;hydrochloride |
| Molecular Formula | C20H31ClN6O5 |
| Purity | ≥95% |
| IUPAC Name | 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methyl]propanamide;hydrochloride |
| InChI | InChI=1S/C20H30N6O5.ClH/c21-6-8-29-10-12-31-14-13-30-11-9-28-7-5-19(27)22-15-17-1-3-18(4-2-17)20-25-23-16-24-26-20;/h1-4,16H,5-15,21H2,(H,22,27);1H |
| InChIKey | MZMSXPAYFMWVQM-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1CNC(=O)CCOCCOCCOCCOCCN)C2=NN=CN=N2.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
