Tetrahydroepiberberine

• CAT Number: R072733
• CAS Number: 38853-67-7
• Molecular Formula: C20H21NO4
• Molecular Weight: 339.39
• Purity: ≥95%
• Synonyms: 16,17-dimethoxy-5,7-dioxa-1-azapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaene
• InChI: InChI=1S/C20H21NO4/c1-22-18-8-13-5-6-21-10-15-12(3-4-17-20(15)25-11-24-17)7-16(21)14(13)9-19(18)23-2/h3-4,8-9,16H,5-7,10-11H2,1-2H3
• InChIKey: UWEHVAXMSWXKRW-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2C3CC4=C(CN3CCC2=C1)C5=C(C=C4)OCO5)OC

Tetrahydroepiberberine (CAT: R072733) is a reduced isoquinoline alkaloid belonging to the protoberberine family, structurally related to berberine and epiberberine. It is typically obtained from medicinal plants such as Coptis chinensis and Berberis species, either naturally or as a metabolic derivative. Unlike berberine, tetrahydroepiberberine lacks the quaternary ammonium group, which alters its physicochemical properties and may improve membrane permeability. Research suggests it exhibits a range of biological activities, including antioxidant, anti-inflammatory, and potential neuroprotective effects. Tetrahydroepiberberine is of interest in pharmacological studies on alkaloid metabolism, structure–activity relationships, and as a candidate scaffold for drug discovery in neurological and metabolic disorders.