Tetrahydro-11-deoxycortisol

• CAT Number: R047820
• CAS Number: 68-60-0
• Molecular Formula: C21H34O4
• Molecular Weight: 350.49
• Purity: ≥95%
• Synonyms: 1-[(3R,5R,8R,9S,10S,13S,14S,17R)-3,17-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-hydroxyethanone
• InChI: InChI=1S/C21H34O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h13-17,22-23,25H,3-12H2,1-2H3/t13-,14-,15-,16+,17+,19+,20+,21+/m1/s1
• InChIKey: UPTAPIKFKZGAGM-FAIYVORSSA-N
• SMILES: CC12CCC(CC1CCC3C2CCC4(C3CCC4(C(=O)CO)O)C)O

Tetrahydro-11-deoxycortisol (Cat No.: R047820) is a metabolite of 11-deoxycortisol, formed through enzymatic hydrogenation of its A-ring. It plays a role in steroidogenesis and serves as a biomarker in the assessment of adrenal gland function and congenital adrenal hyperplasia. This compound is often analyzed in urine to evaluate disorders related to cortisol biosynthesis. Tetrahydro-11-deoxycortisol is used in clinical research to study metabolic pathways of corticosteroids and the effects of enzyme deficiencies in adrenal steroid metabolism, particularly involving 11β-hydroxylase and 21-hydroxylase.

Reference

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.
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[2]. Burren CP, et al. CYP11 beta 1 (11-beta-hydroxylase) deficiency in congenital adrenal hyperplasia. J Paediatr Child Health. 1996 Oct;32(5):433-8.
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