<p>K<sup>+</sup> channels blocker; cholinoreceptors antagonist; ganglioblocker.</p><br /><!–C<SUB>8</SUB>H<SUB>20</SUB>ClN–>, synthetic.</br><p>The exposure of rat tracheal segments to threshold/subthreshold concentrations of TEA produces remarkable Airway Hyperresponsiveness (AH) to cooling provocation [Chand N.].<br /><br /> K<sup>+</sup> channel blockade is involved in the induction of non specific AH in this model [4]. At the concentration of 10 mM: EC<sub>50</sub> = 3.4 �M (1.8 – 6.4). <br /><br /> 1 mM blocks InsP3-induced Ca<sup>2+</sup> release in microsomal fractions isolated from rat brain incubated in media containing 100 mM KCl. Decreases the InsP<sub>3</sub>-induced Ca<sup>2+</sup> release by 80 � 5% [5].</p></br>
| Catalog Number | R064028 |
| CAS Number | 56-34-8 |
| Synonyms | N,N,N-Triethyl-ethanaminium Chloride; Etamon Chloride; TEA; TEA Chloride; TEAC; TEAC 100 |
| Molecular Formula | C8H20ClN |
| Purity | 95% |
| Target | Potassium Channel |
| Solubility | Soluble to 100 mM in sterile water |
| Storage | Desiccate at RT |
| IUPAC Name | tetraethylazanium;chloride |
| InChI | InChI=1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1 |
| InChIKey | YMBCJWGVCUEGHA-UHFFFAOYSA-M |
| SMILES | CC[N+](CC)(CC)CC.[Cl-] |
| Reference | – Barlow, <I>Molec. Pharm</I>. (1971). 7:357-366<br /><br />- Kellet Jr., <I>J. Pharm. Sci.</I> (1965). 54(3):883-887<br /><br />- Eldefrawi M.E. et al., /Permeability of the abdominal nerve cord of the american cockroach, Periplaneta americana L. to quaternary ammonium salts./ <I>J. Exp. Biol</I>. (1967). 46:1-12<br /><br />- Chand N. et al., /Potassium channel blockade induces nonspecific airway hyperractivity in rat isolated trachea: pharmacologic modulation./ <I>Pharm. Comm</I>. (1994). 4(3):173-179<br /><br />- Shah J. et al., /Potassium-channel blockers inhibit inositol triphosphate-induced calcium release in the microsomal fractions isolated from the rat brain./ <I>Biochem. J. </I> (1988). 250:617-620<br /><br /><br /><br /> |
