Tetrabutylammonium Fluoride (1.0 M in THF)

• CAT Number: R019351
• CAS Number: 429-41-4
• Molecular Formula: C16H36FN
• Molecular Weight: 261.47
• Purity: ≥95%
• Synonyms: Tetrabutylammonium Fluoride; Tetrabutylammonium Fluoride; TBAF; N,N,N-Tributyl-1-butanaminium Fluoride
• Storage: -20°C
• IUPAC Name: tetrabutylazanium;fluoride
• InChI: InChI=1S/C16H36N.FH/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;/h5-16H2,1-4H3;1H/q+1;/p-1
• InChIKey: FPGGTKZVZWFYPV-UHFFFAOYSA-M
• SMILES: CCCC[N+](CCCC)(CCCC)CCCC.[F-]

Tetrabutylammonium Fluoride (1.0 M in THF)（Cat No.:R019351）is a powerful, non-aqueous source of fluoride ions widely used in organic synthesis. Dissolved in tetrahydrofuran (THF), this reagent is especially effective for desilylation reactions, such as the removal of silyl protecting groups from alcohols and amines. It is also used in nucleophilic fluorination, elimination, and deprotection protocols. The tetrabutylammonium cation enhances solubility and reactivity in organic media. This stable, ready-to-use solution offers high efficiency under mild conditions, making it an essential tool in synthetic and medicinal chemistry workflows.