For research use only. Not for therapeutic Use.
Tesirine intermediate-1(CAT:I040666) is a key synthetic building block used in the production of Tesirine, a DNA cross-linking cytotoxic payload featured in antibody-drug conjugates (ADCs). This intermediate plays a crucial role in the assembly of the pyrrolobenzodiazepine (PBD) dimer core, enabling the precise construction of potent, targeted anti-cancer agents. Designed for high reactivity and compatibility with linker technologies, Tesirine intermediate-1 supports efficient conjugation and controlled drug release within the tumor microenvironment. Ideal for ADC development and oncology research, this compound ensures reliable performance in the synthesis of next-generation targeted therapeutics.
| CAS Number | 1430738-05-8 |
| Synonyms | (5S)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-1-[5-methoxy-2-nitro-4-tri(propan-2-yl)silyloxybenzoyl]pyrrolidin-3-one |
| Molecular Formula | C28H48N2O7Si2 |
| Purity | ≥95% |
| IUPAC Name | (5S)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-1-[5-methoxy-2-nitro-4-tri(propan-2-yl)silyloxybenzoyl]pyrrolidin-3-one |
| InChI | InChI=1S/C28H48N2O7Si2/c1-18(2)39(19(3)4,20(5)6)37-26-15-24(30(33)34)23(14-25(26)35-10)27(32)29-16-22(31)13-21(29)17-36-38(11,12)28(7,8)9/h14-15,18-21H,13,16-17H2,1-12H3/t21-/m0/s1 |
| InChIKey | IUVUOBISHKAUDN-NRFANRHFSA-N |
| SMILES | CC(C)[Si](C(C)C)(C(C)C)OC1=C(C=C(C(=C1)[N+](=O)[O-])C(=O)N2CC(=O)CC2CO[Si](C)(C)C(C)(C)C)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
