Tesidolumab

• CAT Number: I042400
• CAS Number: 1531594-08-7
• Purity: ≥95%

Tesidolumab (Cat No.: I042400) is a fully human monoclonal antibody that targets complement component C5, a key protein in the terminal complement cascade. By inhibiting C5 cleavage, Tesidolumab prevents the formation of pro-inflammatory and cell-lytic complexes such as C5a and the membrane attack complex (MAC). This mechanism makes it a promising therapeutic for complement-mediated disorders, including paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). Tesidolumab is being evaluated for its ability to reduce inflammation, hemolysis, and tissue damage in these diseases.

Reference

[1]. Jun-Ichi Nishimura, et al. Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria. Haematologica. 2022 Jun 1;107(6):1483-1488.
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