tert-Butyl Dicarbonate

• CAT Number: R051498
• CAS Number: 24424-99-5
• Molecular Formula: C10H18O5
• Molecular Weight: 218.25
• Purity: ≥95%
• Synonyms: BOC2O; C,C’-bis(1,1-Dimethylethyl) Ester Dicarbonic Acid; Bis(1,1-dimethylethyl) Ester Dicarbonic Acid; Oxydi-formic Acid Di-tert-butyl Ester; BOC-anhydride; Bis(1,1-dimethylethyl) Dicarbonate; Bis(tert-butyl) Dicarbonate; Di-tert-butyl Dicarbonate
• Storage: Desiccate at +4C
• IUPAC Name: tert-butyl (2-methylpropan-2-yl)oxycarbonyl carbonate
• InChI: InChI=1S/C10H18O5/c1-9(2,3)14-7(11)13-8(12)15-10(4,5)6/h1-6H3
• InChIKey: DYHSDKLCOJIUFX-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)OC(=O)OC(C)(C)C

tert-Butyl dicarbonate (Cat No.: R051498), with the molecular formula C₉H₁₆O₅, is a widely used reagent in organic synthesis for introducing the Boc (tert-butoxycarbonyl) protecting group to amines. It forms stable carbamate derivatives under mild conditions and is easily removed by acid treatment, making it ideal for multistep syntheses, especially in peptide and pharmaceutical chemistry. Boc protection prevents undesired side reactions involving amines. Its high reactivity and selectivity have made tert-butyl dicarbonate a staple in modern synthetic and medicinal chemistry workflows.