tert-Butoxycarbonyl-L-leucine

• CAT Number: R051207
• CAS Number: 13139-15-6
• Molecular Formula: C11H21NO4
• Molecular Weight: 231.29
• Purity: ≥95%
• Synonyms: N-[(1,1-Dimethylethoxy)carbonyl]-L-leucine; N-(tert-Butoxycarbonyl)-L-leucine; N-(α-tert-Butoxycarbonyl)leucine; N-Boc-L-Leucine; N-Carboxy-L-leucine N-tert-Butyl Ester; N-[(1,1-Dimethylethoxy)carbonyl]leucine; N-tert-Butoxycarbonylleucine; NSC 10869
• Storage: Desiccate at RT
• IUPAC Name: (2S)-4-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid
• InChI: InChI=1S/C11H21NO4/c1-7(2)6-8(9(13)14)12-10(15)16-11(3,4)5/h7-8H,6H2,1-5H3,(H,12,15)(H,13,14)/t8-/m0/s1
• InChIKey: MDXGYYOJGPFFJL-QMMMGPOBSA-N
• SMILES: CC(C)CC(C(=O)O)NC(=O)OC(C)(C)C

tert-Butoxycarbonyl-L-leucine (CAT: R051207) is a protected amino acid widely used in solid-phase and solution-phase peptide synthesis. Featuring a tert-butoxycarbonyl (Boc) group protecting the α-amino function of L-leucine, it prevents undesired side reactions during peptide chain assembly. The hydrophobic isobutyl side chain of L-leucine enhances peptide structural stability and hydrophobic interactions, contributing to protein folding and bioactivity. Boc-L-Leucine is a key intermediate in pharmaceutical development, peptide-based drug design, and biochemical research. Its compatibility with acid-labile deprotection strategies makes it an essential building block for custom peptides and complex peptide analogs.